Computer simulation of drug delivery systems
CEIT had developed computer models to parametrically generate realistic 3D scaffolds architectures to simulate their degradation and consequent drug release. Such models results on a more effective scaffold design, taking advantage of extended in-silico optimisation before starting time-consuming empirical tests.
Figure: evolution of the microstructure of a nanometric fibre containing drugs during its degradation.
Computer modelling of cell migration
CEIT has developed models to simulate cells movement according to the properties of the scaffold where it is placed. These models focus on the process of cell locomotion in a scaffold which is supposed to be a scheme of a fibrous scaffold created by the electrospinning technique, with the subsequent properties. Thus, these models are neither centred in the cell nor centred in the matrix, but simultaneously focuses on both the cell and scaffold.
Figure: velocity of cells simulated for the same substrate but with different dynamic properties of cellular cytoskeleton.
Figure: cell paths predicted for homogeneous random scaffold by in-house developed models.